We're new and evolving group, working on the areas of cell and molecular biology, medicine and genomics.
Work is related to long-standing and current problems in:
- Molecular cardiology and vascular biology (Key words: heart failure, inflammation & atherosclerosis, apoptosis & novel modes of cell death, cardiac remodeling, regeneration, immunobiology of heart and vessels, non-coding RNAs) This involves from in vitro to in vivo modeling of heart related diseases. With the use of various primary cells and cell lines, genetically modified mice and surgery, we induce diseases & pathologically similar conditions to study cardiovascular problems at cellular level.
- Developmental biology (cardiac and vascular development during embryogenesis) With timed mating protocols and by using genetically modified mice, our focus is to study genes in cardiac development and diseases.
BRCA1 is an essential regulator of heart function and survival following myocardial infarction by Shukla, P.C*., Singh, K.K*., Quan, A., Al-Omran, M. et. al. Nature Communication 2 - (2011)
Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction by Hilfiker-Kleiner, D., Shukla, P.C., Klein, G., Fischer, P., Schaefer, A., Stapel, B., Hoch, M., Müller, W., Scherr, M.,Theilmeier, G., Ernst, M., Hilfiker, A., Drexler, H. Circulation 122 (2) - (2010)
Identification of Non-coding RNAs Regulation MLKL/RIPK3 Pathway in Vascular Smooth Muscle Cells: Role of Novel Non-coding RNAs in VSMC Necroptosis ISIRD, SRIC