Ours is an Immunology laboratory that is interested in teasing out the intricacies of immune response and immune tolerance. To that end, we are interested in deciphering the molecular pathways that help maintain the balance between immune response and immune tolerance and utilize that knowledge to better understand autoimmune disease pathogenesis and cancer development.
Immunotherapy is the technique of utilizing one’s own immune system to treat various diseases by inducing, enhancing or suppressing an immune response. The final goal of immunotherapy is to be able to manipulate pertinent immune system components without disturbing the rest. Manipulation of a cellular compartment such as T cells in its entirety or systemic manipulation of immunogical pathways such as costimulatory molecules leads to deleterious side effects like rendering the individual immunocompromised. Therefore, targeted immunotherapeutic strategies which deal with specific cell populations instead of such big-hammer approaches, should be the way forward for the field. Conforming to that idea, we are working to develop T cell-based novel immunotherapeutic strategies in cancer and autoimmunity with the ultimate goal of the development of personalized medicine.
Another interest of the group is to investigate the contribution of skin-resident microflora in regulation of systemic immunity. This will help establish the role of skin-resident microflora on the pathogenesis of autoimmune skin diseases; and tease out the correlation of MHC class I alleles with skin-resident commensals that will help better understand the process of establishment of the microflora and to assess the impact of environmental factors on the colonization process. This is a very important factor in today’s world of extensive migration by the human population out of their native environment. Parallely, in-depth study of the T cell repertoire will be undertaken to understand how the immune system is educated by the skin-resident commensals.
Delivery of siRNAs to dendritic cells using DEC205-targeted lipid nanoparticles to inhibit immune responses by Katakowski JA, Mukherjee G, Wilner SE, Maier K, Harrison MT, DiLorenzo TP, Levy M, and Palliser D Mol. Ther. 24(1) - (2016)
Generation of  cell-specific human T cells by lentiviral transduction and their survival in immunodeficient HLA-transgenic mice by Babad J, Mukherjee G, Follenzi A, Ali R, Shultz L, Santamaria P, Yang O, Roep B, Goldstein H, Greiner D, DiLorenzo TP. . Clin. Exp. Immunol. 179 - (2015)
Glucagon-reactive islet infiltrating CD8 T cells in NOD mice. by **Mukherjee G, Chaparro RJ, Schloss C, Smith C, Bando CD ,**DiLorenzo TP (** corresponding author) Immunology 144(4) - (2015)
Compensatory mechanisms allow undersized anchor-deficient Class I MHC ligands to mediate pathogenic autoreactive T-cell responses. (Selected by Faculty 1000 for exceptional impact) by Lamont D*, Mukherjee G*, Prakash RK, Samanta D, McPhee CG, Kay TWH, Almo SC, DiLorenzo TP, Serreze DV.(* Contributed equally) J Immunol. 193(5) - (2014)
DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8+ T cells independently of PD-1 and PD-L1. by Mukherjee G, Geliebter A, Babad J, Santamaria P, Serreze DV, Freeman GJ, Tarbell KV, Sharpe A, Dilorenzo TP. Int. Immunol 25 - (2013)
Hemolysin induces Toll-like receptor (TLR)-independent apoptosis and multiple TLR-associated parallel activation of macrophages by Chakraborty DC, Mukherjee G, Banerjee P, Banerjee KK, Biswas T. J. Biol. Chem. 286 - (2011)
Structural and functional characterization of a single-chain peptide-MHC molecule that modulates both naive and activated CD8+ T cells. by Samanta D*, Mukherjee G*, Ramagopal UA, Chaparro RJ, Nathenson SG, DiLorenzo TP, Almo SC. (* Contributed equally) Proc. Natl. Acad. Sci. U S A 108 - (2011)
The immunotherapeutic potential of dendritic cells in type 1 diabetes. by Mukherjee G, Dilorenzo TP Clin. Exp. Immunol. 161 - (2010)
Vibrio cholerae hemolysin is apoptogenic to peritoneal B-1a cells but its oligomer shepherd the cells for IgA response by Mukherjee G., Biswas A., Banerjee K. K. and Biswas T. Mol. Immunol 45 - (2008)
Oligomerization of Vibrio cholerae hemolysin induces CXCR3 up-regulation and activation of B-1a cell. by Mukherjee G., Banerjee K. K. and Biswas T Cell. Mol. Immunol 5 - (2008)
Development of Cell-free Peptide-MHC Based Immunotherapeutic Reagent to Manipulate Cytotoxic T Cells in Cancer ISIRD, SRIC